| Heim | Gast | Ergebnis | Spieltag | Datum |
|---|---|---|---|---|
| OH Löwen | KV Oostende | 1:0 | 14 | 05.11.21 - 20:45 Uhr |
| AS Eupen | Zulte-Wareg. | 1:1 | 14 | 06.11.21 - 16:15 Uhr |
| KV Kortrijk | Beerschot | 1:1 | 14 | 06.11.21 - 18:30 Uhr |
| KV Mechelen | Sint-Truiden | 0:1 | 14 | 06.11.21 - 18:30 Uhr |
| Union St-Gill. | Charleroi | 4:0 | 14 | 06.11.21 - 20:45 Uhr |
| Club Brügge | Standard | 2:2 | 14 | 07.11.21 - 13:30 Uhr |
| FC Seraing | AA Gent | 0:0 | 14 | 07.11.21 - 16:00 Uhr |
| Antwerp | Anderlecht | 2:0 | 14 | 07.11.21 - 18:30 Uhr |
| KRC Genk | CS Brügge | 1:1 | 14 | 07.11.21 - 21:00 Uhr |
| P | Verein | Sp. | S | U | N | Tore | Diff. | Pkt. |
|---|---|---|---|---|---|---|---|---|
| 1 | Union St-Gill. | 14 | 10 | 1 | 3 | 33:13 | 20 | 31 |
| 2 | Antwerp | 14 | 8 | 3 | 3 | 25:16 | 9 | 27 |
| 3 | Club Brügge | 14 | 7 | 6 | 1 | 25:17 | 8 | 27 |
| 4 | KV Mechelen | 14 | 7 | 2 | 5 | 25:24 | 1 | 23 |
| 5 | Charleroi | 14 | 6 | 5 | 3 | 25:18 | 7 | 23 |
| 6 | KRC Genk | 14 | 6 | 3 | 5 | 28:23 | 5 | 21 |
| 7 | AS Eupen | 14 | 6 | 3 | 5 | 24:21 | 3 | 21 |
| 8 | Anderlecht | 14 | 5 | 6 | 3 | 27:20 | 7 | 21 |
| 9 | KV Kortrijk | 14 | 5 | 5 | 4 | 17:16 | 1 | 20 |
| 10 | AA Gent | 14 | 5 | 3 | 6 | 21:15 | 6 | 18 |
| 11 | Sint-Truiden | 14 | 5 | 3 | 6 | 15:20 | -5 | 18 |
| 12 | KV Oostende | 14 | 5 | 2 | 7 | 18:25 | -7 | 17 |
| 13 | Standard | 14 | 4 | 5 | 5 | 16:23 | -7 | 17 |
| 14 | OH Löwen | 14 | 3 | 8 | 3 | 18:22 | -4 | 17 |
| 15 | Zulte-Wareg. | 14 | 3 | 5 | 6 | 22:33 | -11 | 14 |
| 16 | FC Seraing | 14 | 4 | 1 | 9 | 16:27 | -11 | 13 |
| 17 | CS Brügge | 14 | 2 | 4 | 8 | 14:21 | -7 | 10 |
| 18 | Beerschot | 14 | 1 | 3 | 10 | 13:28 | -15 | 6 |
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